Recently, my wife had a really bad headache that lasted almost five days. She also felt jittery and anxious. She gets headaches fairly often, but this was different due to the type of pain, the duration, and the additional feeling of what she described as “nervous energy.”

We treated it with medication and ice packs, but it was a very stressful experience for my wife, who obviously has enough to deal with as it is. We were trying to think about what could have triggered the episode, and she told me she had gotten a B12 injection when she was at physical therapy. We did a little searching and discovered that these types of headaches can be a side effect of a B12 injection.

It’s odd, but I also remembered that she had a similar, but much less severe reaction when she was taking B12 in pill form sometime last year. I should really be better about keeping a more complete record about this stuff.

I was just curious if anyone else had a similar experience with side effects from a B12 shot or any other type of high-dose vitamin interactions.